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Our Culture

We are a world-class team translating a pioneering understanding of basic biology into a powerful new class of cancer therapies.

When we say we’re a team, we mean it. We support one another. We challenge one another. We learn from one another. And we always lend a hand.

We have 11,000 square feet of office and lab space in New York City, the greatest city in the world. When we can’t be there in person, we find ways to maintain our connections over Zoom. (Case in point: A recent team cooking class. Who would have thought seasoning paella could be a bonding experience?)

We’re here to turn breakthrough science into therapies that can stop cancer at its outset.

Our Values

Current Openings

Position Location
AD/Director, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients at risk of, or with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.  

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Associate Director/Director at Volastra will work closely with the VP of Biology and scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Associate Director/Director for a project leadership role. The Director will have responsibility for leading complex projects and teams as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. The ideal candidate should have a track-record of project leadership, rigorous scientific standards, deep biological understanding of mechanisms and pathways, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. The candidate should have experience leading the drug discovery programs including coordination of target validation, mechanistic biology, in vivo efficacy, toxicology, and PK/PD workflows. Project responsibilities will include, but are not limited to:

  • Leads project teams to progress drug discovery projects from target validation and discovery implementation to clinical development candidate nomination
  • Designing studies to support biomarker and patient selection strategies
  • Provides scientific perspective and leadership for discovery projects of the company’s early target portfolio focused on chromosomal instability and its role in cancer progression and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights and/or identify new targets
  • Keeps abreast of the latest scientific and competitive developments and applies the knowledge to project strategy
  • Works with internal teams on experimental design and deliver to senior management clearly articulated hypotheses, progress reports and future planning
  • Contributes to building a culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.

Required Skills

  • Experience leading drug discovery projects and managing concurrent activities to progress programs
  • High scientific standards, deep biological understanding of key cancer mechanisms and pathways, ability to identify critical issues or gaps and develop strategies to address them.
  • Excellent communication skills and ability to articulate science and strategy across all levels to varied audiences
  • Ability to effectively manage teams and timelines to meet deadlines
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 7+ years post-graduate experience in a biotech/pharmaceutical setting
  • Experience leading drug discovery programs

 

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

Director of Protein Biochemistry and Structure Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information.

JOB DESCRIPTION

The role of Director, Protein Biochemistry and Structure Biology will work closely with the scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a Director, Protein Biochemistry and Structure Biology for a role on the Biochemistry team. The Director will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who will provide insights towards experiment design and interpretation. The successful candidate will also be instrumental in establishing workflows and infrastructure to support the growing small molecule discovery portfolio. The candidate should also have a track-record of consistent success in structure-enabled drug discovery programs.  The key responsibilities will include:

  • Manage all aspects of protein biochemistry and structural biology and provide expert guidance to CROs
  • Participate in both external and internal team meetings and influence the team decision toward efficient execution of program objectives
  • Excel in multi-tasking and managing protein biochemistry and structural biology aspects for all discovery projects.
  • Prepare scientific documents for publication in conferences, journals and patents

Required Skills

  • Proficient in protein expression in bacterial, insect and mammalian systems, and multi-modal purification (e.g., affinity, ion exchange, size exclusion, hydrophobic interaction)
  • Proficient in (co-)crystallization and compound soaking, X-ray diffraction, structure refinement and determination, and molecular modeling (homology, docking, MD and FEP)
  • Familiar with biochemical and biophysical characterizations (e.g., fluorescence, colorimetry, calorimetry, biosensor, thermal shift, light scattering, mass spectrometry)
  • Highly effective verbal and written communications skills, including across functions
  • Scientific curiosity critical thinking • a drive to deliver meaningful treatments to patients

Preferred Skills (but not required)

  • Experience with CryoEM
  • Experience with in silico and ab initio drug design
  • Experience with machine learning and artificial intelligence

QUALIFICATIONS

A Ph.D. in protein biochemistry and structure biology, or related field, plus at least five years of relevant industrial experience in structure-enabled drug discovery

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

Scientist I, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of cancer.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Scientist at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Scientist for an in vitro biology lab-based role. The Scientist will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills, responsible designing and executing studies as part of a project team, and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of consistent experimentation, experience with in vitro assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights
  • Developing assays to best evaluate therapeutic potential of CIN-targeting therapies
  • Generation of novel cell line models through expression or knockdown/knockout of CIN-relevant genes
  • Using measures of CIN to build novel datasets

Required Skills

  • Cancer cell line culture and genetic engineering (Lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Cell line imaging using immunofluorescence microscopy
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • Measurement of protein/RNA levels through Western blotting, ELISA, qPCR
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Time management to independently meet deadlines

Preferred Skills (but not required)

  • Advanced microscopy techniques such as live imaging, confocal, or high content microscopy
  • In vitro mitotic assays such as cell cycle synchronization and detection of chromosome abnormalities
  • Flow Cytometry
  • Benchling inventory/registry/ELN system

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 5-10+ years cancer biology laboratory experience in an academic and/or industry setting
  • Ability to work independently
  • Excellent communication skills

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

 

 

Senior Research Associate, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of cancer.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Sr. RA at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Senior Research Associate for an in vitro biology lab-based role. The Sr. RA will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who may provide insights towards experiment design and interpretation and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of consistent experimentation, experience with in vitro assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights
  • Developing assays to best evaluate therapeutic potential of CIN-targeting therapies
  • Using measures of CIN to build novel datasets

Required Skills

  • Cancer cell line culture and genetic engineering (Lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Confocal and/or high-content microscopy including live imaging
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • In vitro mitotic assays such as cell cycle synchronization and detection of chromosome abnormalities
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Time management to independently meet deadlines

Preferred Skills (but not required)

  • Western Blot
  • RT-qPCR
  • Flow Cytometry
  • Benchling inventory/registry/ELN system

QUALIFICATIONS

  • Bachelor’s or Master’s Degree in a relevant field such as cell biology or cancer biology
  • 5-10+ years cancer biology laboratory experience in an academic and/or industry setting
  • Ability to work independently
  • Excellent communication skills

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

 

 

Senior Research Associate/Scientist I, Tumor Immunology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

Volastra is seeking a highly motivated Senior Research Associate/Scientist I, Tumor Immunology for an in vitro and in vivo biology lab-based role. The person who fills this position will report to the Director of Immunology and work closely with the scientific team to achieve the company’s scientific and strategic plan.  The Scientist will be responsible for validating novel targets and ensuring the advancement of key drug development programs in the Volastra pipeline as part of the larger scientific team.  The ideal candidate should be someone who takes initiative, is a team player and an independent thinker, and has excellent analytical and communication skills.  Additionally, the candidate should have a good publication track record in peer-reviewed journals, experience developing and implementing in vitro, in vivo and ex vivo immunological assays and expertise characterizing mechanisms of anti-tumor immunity in syngeneic tumor models.

Project responsibilities will include, but are not limited to:

  1. Validate novel immune-oncology targets identified through the company’s CIN/metastasis platform
  2. Develop, validate and execute in vitro, ex vivo, and in vivo immunological experiments
  3. Interrogate the biology of CIN and metastasis to yield new mechanistic insights

Preferred Skills:

  • Experience developing co-culture assays
  • Experience with genetic manipulation (overexpression, RNAi and/or CRISPR/Cas9) of primary immune cells and cancer cells
  • Experience with bioluminescent in vivo imaging to study metastasis
  • Benchling inventory/registry/ELN system

 

 

Senior Scientist, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of cancer.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Senior Scientist at Volastra will work closely with the CSO and scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Senior Scientist for a project leadership and biology lab-based role. The Scientist will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who will provide insights towards experiment design and interpretation and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of project leadership, consistent experimentation, experience with cell-based assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. The candidate should be familiar with the drug discovery process and have experience coordinating target validation, mechanistic biology, in vivo efficacy, toxicology, and PK/PD workflows. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights and identify new targets
  • Managing and coordinating teams (internal or CRO-based) to enable project progression and align with timelines and milestones
  • Designing studies to support biomarker and patient selection strategies

Required Skills

  • Cancer cell line culture and genetic engineering (lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Experience leading projects and managing concurrent activities
  • Ability to work independently and manage timelines to meet deadlines
  • Excellent communication skills and ability to articulate science and strategy across all levels

Preferred Skills (but not required)

  • Design and implementation of genetic or pharmacological screens
  • Confocal and/or high-content microscopy including live imaging
  • Management of CRO activities

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 3+ years post-graduate experience in a biotech/pharmaceutical setting
  • Experience leading drug discovery programs

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.