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Our Culture

We are a world-class team translating a pioneering understanding of basic biology into a powerful new class of cancer therapies.

When we say we’re a team, we mean it. We support one another. We challenge one another. We learn from one another. And we always lend a hand.

We have 11,000 square feet of office and lab space in New York City, the greatest city in the world. When we can’t be there in person, we find ways to maintain our connections over Zoom. (Case in point: A recent team cooking class. Who would have thought seasoning paella could be a bonding experience?)

We’re here to turn breakthrough science into therapies that can stop cancer at its outset.

Our Values

Current Openings

Position Location
Scientist I/II, Computational Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics in metastasis-derived organoids, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.   

JOB DESCRIPTION

The Scientist I/II, Computational Biology will work closely with the Head of Biology and the entire scientific team to achieve the company’s integrative multi-omics approach to understand chromosomal instability in metastatic cancers.  The Scientist, Computational Biology will have responsibility for leading projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Job responsibilities will include, but are not limited to:

  1. Uncover and prioritize novel therapeutic targets through the integrated analysis of both in-house and external datasets (RNA-Seq, Whole Exome Sequencing, etc.)
  2. Development and implementation of novel computational methods using bulk and single-cell expression and genomics data to measure CIN
  3. Understanding, development and implementation of machine learning / artificial intelligence methods for image-based preclinical and clinical data
  4. Work collaboratively with the scientific team including biologists, computational biologists and chemists to answer complex questions in a data-driven manner
  5. Contribute to building a culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.
  6. Clearly communicate key findings to members of the scientific and leadership teams.

 

Required Skills

  • Advanced level coding experience python, bash scripting and R statistical analysis
  • Experience working in Linux environments and high-performance cluster computing
  • Understanding and hands-on experience executing genomic data processing and familiarity with bioinformatics software/tools

 

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

Senior Research Associate, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients at risk of, or with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.  

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Sr. RA at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Senior Scientist for an in vitro biology lab-based role. The Sr. RA will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who may provide insights towards experiment design and interpretation and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of consistent experimentation, experience with in vitro assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights
  • Developing assays to best evaluate therapeutic potential of CIN-targeting therapies
  • Using measures of CIN to build novel datasets

Required Skills

  • Cancer cell line culture and genetic engineering (Lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Confocal and/or high-content microscopy including live imaging
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • In vitro mitotic assays such as cell cycle synchronization and detection of chromosome abnormalities
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Time management to independently meet deadlines

Preferred Skills (but not required)

  • Western Blot
  • RT-qPCR
  • Flow Cytometry
  • Benchling inventory/registry/ELN system

QUALIFICATIONS

  • Bachelor’s or Master’s Degree in a relevant field such as cell biology or cancer biology
  • 5-10+ years cancer biology laboratory experience in an academic and/or industry setting
  • Ability to work independently
  • Excellent communication skills

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

 

 

Senior Scientist, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients at risk of, or with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.  

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Senior Scientist at Volastra will work closely with the CSO and scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Senior Scientist for a project leadership and biology lab-based role. The Scientist will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who will provide insights towards experiment design and interpretation and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of project leadership, consistent experimentation, experience with cell-based assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. The candidate should be familiar with the drug discovery process and have experience coordinating target validation, mechanistic biology, in vivo efficacy, toxicology, and PK/PD workflows. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights and identify new targets
  • Managing and coordinating teams (internal or CRO-based) to enable project progression and align with timelines and milestones
  • Designing studies to support biomarker and patient selection strategies

Required Skills

  • Cancer cell line culture and genetic engineering (lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Experience leading projects and managing concurrent activities
  • Ability to work independently and manage timelines to meet deadlines
  • Excellent communication skills and ability to articulate science and strategy across all levels

Preferred Skills (but not required)

  • Design and implementation of genetic or pharmacological screens
  • Confocal and/or high-content microscopy including live imaging
  • Management of CRO activities

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 3+ years post-graduate experience in a biotech/pharmaceutical setting
  • Experience leading drug discovery programs

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.