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Our Culture

We are a world-class team translating a pioneering understanding of basic biology into a powerful new class of cancer therapies.

When we say we’re a team, we mean it. We support one another. We challenge one another. We learn from one another. And we always lend a hand.

We have 11,000 square feet of office and lab space in New York City, the greatest city in the world. When we can’t be there in person, we find ways to maintain our connections over Zoom. (Case in point: A recent team cooking class. Who would have thought seasoning paella could be a bonding experience?)

We’re here to turn breakthrough science into therapies that can stop cancer at its outset.

Our Values

Current Openings

Position Location
Director, Project Management New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

JOB DESCRIPTION

The role of Director, Project Management will work closely with the management and scientific teams to achieve the company’s overall research, development and operational plans.  The Director, Project Management will partner with the scientific and clinical project leads to successfully shape and execute the drug development strategies of our early and late pre-clinical programs, as well as the project lifecycle plan.  Job responsibilities will include, but are not limited to:

  1. Maintain project timelines (in particular IND to DC timelines) with input from the functional departments and scientific project leaders, and ensure that the corporate timelines are aligned with project timelines   
  2. Develop a strategic development plan in partnership with the project leader to govern project strategy
  3. Proactively identify risks in the project timelines in regard to key milestones and deliverables and work closely with the scientific and functional leaders to mitigate downstream impacts
  4. Work closely with the scientific project leader in fostering a high-performing and high functioning team through the creation of team norms and operating principles
  5. Facilitate effective, science-based business decisions including scenario planning, highlighting all potential downstream impacts of strategic decision making (including resource allocation, team capacity, risk and overall portfolio management)
  6. Develop and coordinate ongoing resource planning across functions to ensure adequate resources are applied to the project at any given time
  7. Manage the scientific communications plans for the project(s) and integrate with overall corporate communications plan
  8. Prepare monthly progress reports and ad hoc reports as required
  9. Assist in managing key alliances within the organization, this could include both contract and relationship management
  10. Responsible for the conduct and deliverables of Project Team meetings
  11. Help lead corporate planning cycle on a yearly basis, including goal setting, budgeting and strategic short and long term plan. 
  12. Coordinate preparation for board meetings. 

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Director, Project Management will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

Research Associate/Senior Research Associate, Data Engineering New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The Research Associate/Senior Research Associate, Data Engineering will work closely with the Head of Data Science and the entire scientific team to achieve the company’s integrative data-centric approach to understand chromosomal instability in metastatic cancers.  If you enjoy the prospect of improving the lives of cancer patients using advanced computational methods, this may the role for you.

In your first 6 months, you will have the opportunity to materially impact the Volastra pipeline with data engineering support towards target identification, patient selection, and research prioritization.  We rely on both proprietary and external data from genomics, pre-clinical and clinical microscopy, chemoinformatics, proteomics, and more. We utilize cutting-edge data storage and access tools to operate in such a content-rich but high variance data ecosystem.

You’ll design unique data storage and access architectures, enabling our data science, biology, and chemistry teams to arrive at the best decisions faster.  You’ll be given the chance to explore novel techniques, including multi-modality data fusion, all while improving performance of our laboratory data generation systems.  We enjoy working with ever larger and complex data sets to improve human health, and hope you do too!

You will also:

  • Work collaboratively with the scientific team including biologists, computational biologists, data scientists, and chemists to answer complex questions in a data-driven manner.
  • Contribute to building a culture that embraces technical excellence and integrity with a sense of collaboration internally and externally.
  • Clearly communicate key findings to members of the scientific and leadership teams.

You have:

  • Experience identifying data bottlenecks, and a track record of architecting and implements solutions to them
  • Developed end-to-end batch and real-time data pipelines, and launched them into production
  • Expertise with cloud computing, preferably aws (EC2, s3, redshift, dynamo, neptune, etc.)
  • Developed new tools to help end-users consume necessary data more quickly
  • Maintain and troubleshoot existing data pipelines
  • Familiarity with novel data store solutions beyond SQL, such a key:value stores (BigTable, dynamo), and graph databases (neptune, neo4j)
  • 3+ years of previous work experience in data engineering roles, preferably related to biological, chemical, or medical data types
  • A passion for correct, reproducible, re-usable, and well-documented code, preferably in python, R, or similar language(s)
  • Some experience in analyzing multimodal datasets
  • Some experience with big data tools e.g. Hadoop, Spark
  • (Preferred) A graduate degree in a quantitative discipline (statistics, computer science, mathematics, engineering, etc)
Scientist I, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of cancer.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Scientist at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Scientist for an in vitro biology lab-based role. The Scientist will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills, responsible designing and executing studies as part of a project team, and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of consistent experimentation, experience with in vitro assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights
  • Developing assays to best evaluate therapeutic potential of CIN-targeting therapies
  • Generation of novel cell line models through expression or knockdown/knockout of CIN-relevant genes
  • Using measures of CIN to build novel datasets

Required Skills

  • Cancer cell line culture and genetic engineering (Lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Cell line imaging using immunofluorescence microscopy
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • Measurement of protein/RNA levels through Western blotting, ELISA, qPCR
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Time management to independently meet deadlines

Preferred Skills (but not required)

  • Advanced microscopy techniques such as live imaging, confocal, or high content microscopy
  • In vitro mitotic assays such as cell cycle synchronization and detection of chromosome abnormalities
  • Flow Cytometry
  • Benchling inventory/registry/ELN system

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 5-10+ years cancer biology laboratory experience in an academic and/or industry setting
  • Ability to work independently
  • Excellent communication skills

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

 

 

Senior Research Associate, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of cancer.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Sr. RA at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Senior Research Associate for an in vitro biology lab-based role. The Sr. RA will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who may provide insights towards experiment design and interpretation and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of consistent experimentation, experience with in vitro assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights
  • Developing assays to best evaluate therapeutic potential of CIN-targeting therapies
  • Using measures of CIN to build novel datasets

Required Skills

  • Cancer cell line culture and genetic engineering (Lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Confocal and/or high-content microscopy including live imaging
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • In vitro mitotic assays such as cell cycle synchronization and detection of chromosome abnormalities
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Time management to independently meet deadlines

Preferred Skills (but not required)

  • Western Blot
  • RT-qPCR
  • Flow Cytometry
  • Benchling inventory/registry/ELN system

QUALIFICATIONS

  • Bachelor’s or Master’s Degree in a relevant field such as cell biology or cancer biology
  • 5-10+ years cancer biology laboratory experience in an academic and/or industry setting
  • Ability to work independently
  • Excellent communication skills

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

 

 

Senior Research Associate/Scientist I, Bioinformaticist New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The Bioinformaticist, Senior RA/Scientist I will work closely with the Head of Data Science and the entire scientific team to achieve the company’s integrative data-centric approach to understand chromosomal instability in metastatic cancers.  If you enjoy the prospect of improving the lives of cancer patients using advanced computational methods, this may the role for you.

In your first 6 months, you will have the opportunity to materially impact the Volastra pipeline with novel analyses informing target selection and validation using integrative analysis of both proprietary and external datasets (RNA-Seq, Whole Exome Sequencing, etc.).  You’ll build unique data pipelines, as well as analyze their outputs for our project teams.  You’ll be given the chance to explore novel statistical inference techniques, which could include multi-modality data fusion (genomic, imaging, and clinical data), machine learning, and dynamic systems modeling.

You will also:

  1. Work collaboratively with the scientific team including biologists, computational biologists, data scientists, and chemists to answer complex questions in a data-driven manner.
  2. Contribute to building a culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.
  3. Clearly communicate key findings to members of the scientific and leadership teams.

You have:

  • A deep understanding of statistical analysis methods, data engineering, and genomic pipeline development
  • Scientific or quantitative computing experience (Python or R), plus Unix
  • Familiarity with high-performance cluster and cloud computing (aws, Azure) and reproducible scientific workflow managers such as NextFlow, CWL, git, etc..
  • Familiarity with next generation sequencing dataset and public datasets such as TCGA,GTEX, NCBI GEO
  • The ability to tell a story with data (analysis, data visualization)
  • An understanding of best practices in reproducible scientific computing (git, documentation, object oriented programming, etc.)
  • 3+ years of previous work experience in bioinformatics-related roles
  • Knowledge of common bioinformatics software and toolkits to process and analyze genomic datasets such as samtools, GATK, STAR
  • Prior experience in cancer biology is preferred
  • (Preferred) A graduate degree in bioinformatics, computational biology, bioengineering, or other relevant quantitative discipline (statistics, mathematics, engineering, etc.)

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

Senior Research Associate/Scientist I, Tumor Immunology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

Volastra is seeking a highly motivated Senior Research Associate/Scientist I, Tumor Immunology for an in vitro and in vivo biology lab-based role. The person who fills this position will report to the Director of Immunology and work closely with the scientific team to achieve the company’s scientific and strategic plan.  The Scientist will be responsible for validating novel targets and ensuring the advancement of key drug development programs in the Volastra pipeline as part of the larger scientific team.  The ideal candidate should be someone who takes initiative, is a team player and an independent thinker, and has excellent analytical and communication skills.  Additionally, the candidate should have a good publication track record in peer-reviewed journals, experience developing and implementing in vitro, in vivo and ex vivo immunological assays and expertise characterizing mechanisms of anti-tumor immunity in syngeneic tumor models.

Project responsibilities will include, but are not limited to:

  1. Validate novel immune-oncology targets identified through the company’s CIN/metastasis platform
  2. Develop, validate and execute in vitro, ex vivo, and in vivo immunological experiments
  3. Interrogate the biology of CIN and metastasis to yield new mechanistic insights

Preferred Skills:

  • Experience developing co-culture assays
  • Experience with genetic manipulation (overexpression, RNAi and/or CRISPR/Cas9) of primary immune cells and cancer cells
  • Experience with bioluminescent in vivo imaging to study metastasis
  • Benchling inventory/registry/ELN system

 

 

Senior Scientist, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of cancer.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 11,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Senior Scientist at Volastra will work closely with the CSO and scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Senior Scientist for a project leadership and biology lab-based role. The Scientist will have responsibility for leading and executing projects as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who will provide insights towards experiment design and interpretation and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of project leadership, consistent experimentation, experience with cell-based assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. The candidate should be familiar with the drug discovery process and have experience coordinating target validation, mechanistic biology, in vivo efficacy, toxicology, and PK/PD workflows. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights and identify new targets
  • Managing and coordinating teams (internal or CRO-based) to enable project progression and align with timelines and milestones
  • Designing studies to support biomarker and patient selection strategies

Required Skills

  • Cancer cell line culture and genetic engineering (lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Cell-based phenotypic assays such as proliferation, cytotoxicity, migration or invasion
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Experience leading projects and managing concurrent activities
  • Ability to work independently and manage timelines to meet deadlines
  • Excellent communication skills and ability to articulate science and strategy across all levels

Preferred Skills (but not required)

  • Design and implementation of genetic or pharmacological screens
  • Confocal and/or high-content microscopy including live imaging
  • Management of CRO activities

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 3+ years post-graduate experience in a biotech/pharmaceutical setting
  • Experience leading drug discovery programs

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.