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Our Culture

We are a world-class team translating a pioneering understanding of basic biology into a powerful new class of cancer therapies.

When we say we’re a team, we mean it. We support one another. We challenge one another. We learn from one another. And we always lend a hand.

We have 15,000 square feet of office and lab space in New York City, the greatest city in the world. When we can’t be there in person, we find ways to maintain our connections over Zoom. (Case in point: A recent team cooking class. Who would have thought seasoning paella could be a bonding experience?)

We’re here to turn breakthrough science into therapies that can stop cancer at its outset.

Our Values

Current Openings

Position Location
AD/Director, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients at risk of, or with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.  

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Associate Director/Director at Volastra will work closely with the VP of Biology and scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Associate Director/Director for a project leadership role. The Director will have responsibility for leading complex projects and teams as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. The ideal candidate should have a track-record of project leadership, rigorous scientific standards, deep biological understanding of mechanisms and pathways, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. The candidate should have experience leading the drug discovery programs including coordination of target validation, mechanistic biology, in vivo efficacy, toxicology, and PK/PD workflows. Project responsibilities will include, but are not limited to:

  • Leads project teams to progress drug discovery projects from target validation and discovery implementation to clinical development candidate nomination
  • Designing studies to support biomarker and patient selection strategies
  • Provides scientific perspective and leadership for discovery projects of the company’s early target portfolio focused on chromosomal instability and its role in cancer progression and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights and/or identify new targets
  • Keeps abreast of the latest scientific and competitive developments and applies the knowledge to project strategy
  • Works with internal teams on experimental design and deliver to senior management clearly articulated hypotheses, progress reports and future planning
  • Contributes to building a culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.

Required Skills

  • Experience leading drug discovery projects and managing concurrent activities to progress programs
  • High scientific standards, deep biological understanding of key cancer mechanisms and pathways, ability to identify critical issues or gaps and develop strategies to address them.
  • Excellent communication skills and ability to articulate science and strategy across all levels to varied audiences
  • Ability to effectively manage teams and timelines to meet deadlines
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 7+ years post-graduate experience in a biotech/pharmaceutical setting
  • Experience leading drug discovery programs

 

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

Associate Director/Director/Sr Director, DMPK New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients at risk of, or with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.  

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinics and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION 

The Associate Director/Director/Senior Director of DMPK will report directly to the Vice President of Chemistry and work closely will partner with the Scientific Project Leaders to successfully shape and execute the relevant PK/ADME portions of the project to support the overall drug development strategies from early discovery through clinical development.  Job responsibilities will include, but are not limited to:

  1. Serve as the DMPK subject matter expert for nonclinical development
  2. Manage CROs in the conduct of in vitro/in vivo ADME and DMPK modeling studies
  3. Prepare strategic, innovative, and scientifically sophisticated PK/ADME drug development strategies that meet regulatory requirements and program goals
  4. Design, execute and interpret non-clinical pharmacology, toxicology, DMPK and translational studies supporting progression of therapies from early discovery through first in human and proof of concept clinical studies
  5. Prepare high quality preclinical and translational DMPK work packages to support projects in lead optimization and clinical candidate selection as well as any associated regulatory filings
  6. Design preclinical studies and report results to project teams to evaluate and optimize series and compounds towards a selected candidate with acceptable and predictable clinical PK properties and drug-drug interaction profile
  7. Collaborate with scientific team and clinical development to characterize human pharmacokinetics, metabolism, and biopharmaceutics of clinical compounds
  8. Assess and communicate DMPK results to senior management to support key go, no-go decisions
  9. Build, manage and coach a team of high performing subject matter experts to support research and clinical programs, as needed

Skills and requirements

  • Ph.D. degree in relevant scientific field and greater than 8 years’ experience with DMPK in drug discovery in a Pharmaceutical or Biotech setting, or M.Sc. degree and greater than 12 years relevant industrial experience.
  • Broad experience with in vitro and in vivo preclinical assays and their application to predict human ADME and potential DDI.
  • Ability to collaborate on the discovery of clinical leads, and the preclinical characterization of leads to identify clinical candidates
  • Experience with IND filings
  • Strong communication skills, with the ability to work on fast-moving, collaborative, cross-functional teams

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Associate Director/Director/Senior Director of DMPK will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.

 

Biology Intern New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum. Volastra is dedicated to the discovery and development of treatments for patients with cancer. The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease. Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch. Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team. This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Biology Intern at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan. Volastra is seeking a highly motivated intern for an in vitro biology lab-based role. The intern will have responsibility for designing and executing experiments under the guidance of Volastra scientists to advance programs in Volastra’s pipeline targeting chromosomally unstable (CIN) cancers. Our ideal candidate demonstrates intellectual curiosity and a desire to learn cutting edge techniques in drug development.

Project responsibilities will include, but are not limited to:

1. Validate potential targets of CIN and metastasis using genetic engineering techniques
2. Develop cutting edge 2D and 3D cell culture models to yield new mechanistic insights in CIN biology
3. Work with the team to advance drug development of key programs

Qualifications

1. Independent experience culturing human cell lines in a research laboratory
2. Sterile technique as it pertains to tissue culture
3. Molecular biology techniques such as PCR, RT-qPCR and western blot

Interested candidates can visit www.volastratx.com for more information or contact Alan Chiu (achiu@volastratx.com) directly with a CV and cover letter.

Director, Data Science New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information.

JOB DESCRIPTION

The Director, Data Science will work closely with the Head of Data Science and the entire scientific team to achieve the company’s integrative data-centric approach to identify novel targets and develop therapeutics to treat chromosomally unstable cancers.  If you enjoy the prospect of improving the lives of cancer patients using advanced computational methods, this may the role for you.

In your first 6 months, your team will have the opportunity to materially impact the Volastra pipeline with novel analyses informing target selection and validation using integrative methods on both proprietary and external datasets (RNA-Seq, Whole Exome Sequencing, etc.).  Your team will build unique data pipelines as well as analyze their outputs for our project teams.  You and your team have the opportunity to explore novel statistical inference techniques, which could include multi-modality data fusion (genomic, imaging, and clinical data), machine learning, and dynamic systems modeling.

You will also:

  1. Work collaboratively with the scientific team including biologists, computational biologists, data scientists, and chemists to answer complex questions in a data-driven manner
  2. Contribute to building a team and culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.
  3. Clearly communicate key findings to members of the scientific and leadership teams.
  4. Provide leadership to less experienced staff, including setting priorities, managing to a deadline, and fostering development opportunities for those on your team.

You have:

  • A graduate degree in bioinformatics, computational biology, bioengineering, or other relevant quantitative discipline (statistics, mathematics, engineering, etc)
  • 5+ years of previous work experience in data science-related roles at the intersection of biology, immunology, or translational medicine
  • A deep understanding of statistical analysis methods, data engineering, and genomic pipeline development
  • Scientific or quantitative computing experience (Python or R), plus bash scripting
  • Familiarity with high-performance cluster and cloud computing (aws, Azure, spark)
  • An understanding of best practices in reproducible scientific computing (git, documentation, object oriented programming, etc)
  • Familiarity with common bioinformatics software and toolkits, such as NextFlow, deseq2, samtools, GATK, and STAR
  • Experience working with multidisciplinary teams and leveraging large public datasets to facilitate novel target discovery and refine patient selection strategies.
  • Past involvement or leadership in immune-oncology projects is a plus.
  • The ability to tell a story with data (analysis, data visualization)

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

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Project Lead/Development Team Lead New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

This exciting role of Project Lead/Development Team Lead will work closely with the scientific, clinical and operational teams to achieve the company’s strategic plan.  Volastra is seeking a versatile Project Lead/Development Team Lead or a senior role on the strategy and operations team to lead key cross functional projects and ensure deliverables are achieved. The Project and Portfolio Leader will have responsibility for leading and executing projects as part of the team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent leadership and communication skills who will provide insights towards experiment design and interpretation. The successful candidate will also be instrumental in establishing workflows and infrastructure to support the Project Leadership group.  The key responsibilities will include:

  • Provide visibly and dynamic leadership of core project teams to develop/refine integrated development plans and execute cross-functional tactical plans based on the Scientific Governance Committee approved development/life cycle strategy
  • Accountable for timely, cost effective and high-quality execution of Scientific Governance Committee approved program, including program’s budget, timelines, and resource allocation to achieve program’s goals
  • Provide a continuously updated and balanced appraisal of the program status, including risk, cost, and value to stakeholders
  • Responsible for alignment of functional plans with approved project plans and ensure high quality execution
  • Primary interface with governance bodies and responsible for implementing decisions
  • Ensure alignment between the program strategy and tactical execution
  • Ensure coherence between the global project plan (timeline, resource allocation, Target Product Profile) and corporate and line management objectives
  • Ensure team focus and accountability to achieve team goals
  • Monitor program progress and develop corrective actions if deviations occur
  • Ensure that all global core program team members understand project goals and objectives, current project plan and schedule, critical path activities and activities that may become critical path activities
  • Work closely with all project team members to ensure close follow-up on execution and proactive evaluation and resolution of potential risks and challenges
  • Make program/compound decisions within the scope approved by Scientific Governance Committee
  • Partner with line function management deliver goals and escalate issues to appropriate governance committee if needed
  • Interpret and communicate key clinical trial results and key regulatory milestones, communications, and engagements
  • Develop and partner with team on an overall communication strategy, as well as the publication strategy and plan, PR plan and broad internal/external communications
  • Manage project manager(s) working on projects within the overall program
  • Seek and develop high performance team and individual behaviors (challenge, motivate, reward), including development of team members.
  • Provide input to the development of corporate goals

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Project Lead/Development Team Lead will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.