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Our Culture

We are a world-class team translating a pioneering understanding of basic biology into a powerful new class of cancer therapies.

When we say we’re a team, we mean it. We support one another. We challenge one another. We learn from one another. And we always lend a hand.

We have 15,000 square feet of office and lab space in New York City, the greatest city in the world. When we can’t be there in person, we find ways to maintain our connections over Zoom. (Case in point: A recent team cooking class. Who would have thought seasoning paella could be a bonding experience?)

We’re here to turn breakthrough science into therapies that can stop cancer at its outset.

Our Values

Current Openings

Position Location
AD/Director, Biology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients at risk of, or with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.  

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Associate Director/Director at Volastra will work closely with the VP of Biology and scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated Associate Director/Director for a project leadership role. The Director will have responsibility for leading complex projects and teams as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. The ideal candidate should have a track-record of project leadership, rigorous scientific standards, deep biological understanding of mechanisms and pathways, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. The candidate should have experience leading the drug discovery programs including coordination of target validation, mechanistic biology, in vivo efficacy, toxicology, and PK/PD workflows. Project responsibilities will include, but are not limited to:

  • Leads project teams to progress drug discovery projects from target validation and discovery implementation to clinical development candidate nomination
  • Designing studies to support biomarker and patient selection strategies
  • Provides scientific perspective and leadership for discovery projects of the company’s early target portfolio focused on chromosomal instability and its role in cancer progression and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights and/or identify new targets
  • Keeps abreast of the latest scientific and competitive developments and applies the knowledge to project strategy
  • Works with internal teams on experimental design and deliver to senior management clearly articulated hypotheses, progress reports and future planning
  • Contributes to building a culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.

Required Skills

  • Experience leading drug discovery projects and managing concurrent activities to progress programs
  • High scientific standards, deep biological understanding of key cancer mechanisms and pathways, ability to identify critical issues or gaps and develop strategies to address them.
  • Excellent communication skills and ability to articulate science and strategy across all levels to varied audiences
  • Ability to effectively manage teams and timelines to meet deadlines
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint

QUALIFICATIONS

  • PhD in a relevant field such as cell biology or cancer biology
  • 7+ years post-graduate experience in a biotech/pharmaceutical setting
  • Experience leading drug discovery programs

 

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

Associate Director/Director, Program Management New York, NY

COMPANY

Volastra Therapeutics, Inc. is a well-funded, privately held, platform-based biotechnology company in New York City dedicated to the discovery and development of life-saving treatments for patients with treatment resistant cancers. Volastra uses a multi-omics driven approach to identify and quickly validate novel therapies targeting the chromosomal instability (CIN) pathway, which plays a central role in the formation, progression, and maintenance of cancer. The team at Volastra is working towards shifting the treatment paradigm in oncology and is poised to bring its first development candidate to the clinic, while continuing to build out its pipeline. To learn more about Volastra please visit www.volastratx.com

JOB DESCRIPTION

Volastra is seeking a highly motivated and experienced individual who will be responsible for supporting cross-functional drug development activities to achieve the company’s scientific and strategic goals. The Associate Director/Director, Program Management will partner with program and functional leaders and work in close collaboration with the Development Team, sub-teams and co-development partners to advance the company’s R&D portfolio, shape and execute the project and portfolio strategies through the project lifecycle. The successful candidate displays a diverse range of interpersonal skills, has effective communication, organizational, analytical, and problem-solving skills, coupled with enthusiasm, motivation, and ability to lead and collaborate within teams. The role reports to and will work closely with the VP, Development Leadership.

This is an exciting opportunity for a qualified candidate to join the dedicated and talented team at Volastra in support of the company’s growth and development efforts. Volastra is a lean team of dedicated individuals working to advance therapies for patients with advanced cancer. As such, the individual will have the opportunity to work on projects and take on responsibilities that may fall outside of his/her scope of work. 

JOB RESPONSIBILITIES

  • Work in coordination with the Development Lead as well as scientific and functional leads to develop and maintain high-quality, integrated project plans and timelines that align with overall program and corporate strategy and drive communication, scenario planning and decision making
  • Facilitate effective, science-based business decisions through scenario planning, highlighting potential downstream impacts of strategic decision making (including resource allocation, team capacity, risk and overall portfolio management)
  • Facilitate the identification, management and communication of key program risks and their associated mitigation and contingency plans
  • Work collaboratively and cross-functionally to coordinate, influence and manage efforts to ensure seamless execution of the global development strategy
  • Provide program and project management support for key functional activities including functional sub-team and working group meeting support, regulatory submission planning and management of external contractors/vendors as indicated
  • In partnership with the Development Team prepare a Strategic Development Plan to govern program strategy
  • Develop and coordinate ongoing resource planning across functions to ensure adequate resources are applied to the project at any given time
  • Leverage strong project and organizational knowledge, leadership and facilitation skills to optimize team meetings and facilitate effective governance and decision making
  • Develop and implement stage appropriate and value-added processes, best practices and tools (integrated timelines, TPPs, stage gate process, governance, core & sub team processes) to increase efficiency and consistency of global product development and team processes/deliverables
  • Advance program and alliance management best practices and contribute to the operational excellence of Volastra with a focus on continuous improvement
  • Build and leverage relationships and networks and contribute to fostering high-performing and high functioning teams through team norms and operating principles; proactively identify opportunities and removing obstacles to drive business results
  • Manage the scientific communications plans for the project(s) and integrate with overall corporate communications plan
  • Prepare monthly progress reports and ad hoc reports as required
  • Support planning and integration of early research efforts in support of the company pipeline and strategic goals
  • Other responsibilities as assigned

QUALIFICATIONS

  • Bachelor’s Degree (BSc) required; advanced degree (MSc, PhD, PharmD) preferred. 
  • Minimum of 5-7 years of experience in the pharmaceutical/biotech industry, with experience managing cross-functional drug development programs
  • Drug development knowledge with understanding of functions relevant to advancing the program, such as Research, Preclinical, Clinical, Manufacturing, Regulatory and Commercial
  • Excellent business acumen, demonstrated ability to align teams to strategy to achieve business and project objectives
  • Experience leading and facilitating project team meetings, cross-functional communication and decision making, and ensuring ongoing alignment with internal/external stakeholders
  • A proactive and strategic thinker, with strong facilitation, problem-solving and issue resolution skills
  • Highly collaborative with outstanding communication and relationship management skills, high emotional intelligence
  • Adaptive leadership style adept at influencing teams without formal authority and ability to work effectively with cross-functional teams in a highly matrixed global organization
  • PMP credential and experience with latest PM tools, software and processes is valued
  • Oncology drug development experience and prior experience working with external consultants/vendors is desirable 
  • Job Location: New York City, hybrid
Associate Director/Director/Sr Director, DMPK New York, NY

COMPANY

Volastra Therapeutics, Inc. is a platform-based biotechnology company in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra Therapeutics is dedicated to the discovery and development of treatments for patients at risk of, or with metastatic cancers.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of metastasis.  Utilizing an integrated multi-omics approach with high content analytics, the team at Volastra plans to identify and quickly validate novel therapies to shift the treatment paradigm in metastatic cancers.  

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinics and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION 

The Associate Director/Director/Senior Director of DMPK will report directly to the Vice President of Chemistry and work closely will partner with the Scientific Project Leaders to successfully shape and execute the relevant PK/ADME portions of the project to support the overall drug development strategies from early discovery through clinical development.  Job responsibilities will include, but are not limited to:

  1. Serve as the DMPK subject matter expert for nonclinical development
  2. Manage CROs in the conduct of in vitro/in vivo ADME and DMPK modeling studies
  3. Prepare strategic, innovative, and scientifically sophisticated PK/ADME drug development strategies that meet regulatory requirements and program goals
  4. Design, execute and interpret non-clinical pharmacology, toxicology, DMPK and translational studies supporting progression of therapies from early discovery through first in human and proof of concept clinical studies
  5. Prepare high quality preclinical and translational DMPK work packages to support projects in lead optimization and clinical candidate selection as well as any associated regulatory filings
  6. Design preclinical studies and report results to project teams to evaluate and optimize series and compounds towards a selected candidate with acceptable and predictable clinical PK properties and drug-drug interaction profile
  7. Collaborate with scientific team and clinical development to characterize human pharmacokinetics, metabolism, and biopharmaceutics of clinical compounds
  8. Assess and communicate DMPK results to senior management to support key go, no-go decisions
  9. Build, manage and coach a team of high performing subject matter experts to support research and clinical programs, as needed

Skills and requirements

  • Ph.D. degree in relevant scientific field and greater than 8 years’ experience with DMPK in drug discovery in a Pharmaceutical or Biotech setting, or M.Sc. degree and greater than 12 years relevant industrial experience.
  • Broad experience with in vitro and in vivo preclinical assays and their application to predict human ADME and potential DDI.
  • Ability to collaborate on the discovery of clinical leads, and the preclinical characterization of leads to identify clinical candidates
  • Experience with IND filings
  • Strong communication skills, with the ability to work on fast-moving, collaborative, cross-functional teams

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Associate Director/Director/Senior Director of DMPK will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.

 

Biology Intern New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum. Volastra is dedicated to the discovery and development of treatments for patients with cancer. The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease. Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch. Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team. This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Biology Intern at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan. Volastra is seeking a highly motivated intern for an in vitro biology lab-based role. The intern will have responsibility for designing and executing experiments under the guidance of Volastra scientists to advance programs in Volastra’s pipeline targeting chromosomally unstable (CIN) cancers. Our ideal candidate demonstrates intellectual curiosity and a desire to learn cutting edge techniques in drug development.

Project responsibilities will include, but are not limited to:

1. Validate potential targets of CIN and metastasis using genetic engineering techniques
2. Develop cutting edge 2D and 3D cell culture models to yield new mechanistic insights in CIN biology
3. Work with the team to advance drug development of key programs

Qualifications

1. Independent experience culturing human cell lines in a research laboratory
2. Sterile technique as it pertains to tissue culture
3. Molecular biology techniques such as PCR, RT-qPCR and western blot

Interested candidates can visit www.volastratx.com for more information or contact Alan Chiu (achiu@volastratx.com) directly with a CV and cover letter.

Director, Data Science New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information.

JOB DESCRIPTION

The Director, Data Science will work closely with the Head of Data Science and the entire scientific team to achieve the company’s integrative data-centric approach to identify novel targets and develop therapeutics to treat chromosomally unstable cancers.  If you enjoy the prospect of improving the lives of cancer patients using advanced computational methods, this may the role for you.

In your first 6 months, your team will have the opportunity to materially impact the Volastra pipeline with novel analyses informing target selection and validation using integrative methods on both proprietary and external datasets (RNA-Seq, Whole Exome Sequencing, etc.).  Your team will build unique data pipelines as well as analyze their outputs for our project teams.  You and your team have the opportunity to explore novel statistical inference techniques, which could include multi-modality data fusion (genomic, imaging, and clinical data), machine learning, and dynamic systems modeling.

You will also:

  1. Work collaboratively with the scientific team including biologists, computational biologists, data scientists, and chemists to answer complex questions in a data-driven manner
  2. Contribute to building a team and culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.
  3. Clearly communicate key findings to members of the scientific and leadership teams.
  4. Provide leadership to less experienced staff, including setting priorities, managing to a deadline, and fostering development opportunities for those on your team.

You have:

  • A graduate degree in bioinformatics, computational biology, bioengineering, or other relevant quantitative discipline (statistics, mathematics, engineering, etc)
  • 5+ years of previous work experience in data science-related roles at the intersection of biology, immunology, or translational medicine
  • A deep understanding of statistical analysis methods, data engineering, and genomic pipeline development
  • Scientific or quantitative computing experience (Python or R), plus bash scripting
  • Familiarity with high-performance cluster and cloud computing (aws, Azure, spark)
  • An understanding of best practices in reproducible scientific computing (git, documentation, object oriented programming, etc)
  • Familiarity with common bioinformatics software and toolkits, such as NextFlow, deseq2, samtools, GATK, and STAR
  • Experience working with multidisciplinary teams and leveraging large public datasets to facilitate novel target discovery and refine patient selection strategies.
  • Past involvement or leadership in immune-oncology projects is a plus.
  • The ability to tell a story with data (analysis, data visualization)

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. 

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Research Associate / Senior Research Associate, Biology - TEMP New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Leveraging these insights we will identify and quickly validate novel therapies to shift the treatment paradigm in the toughest to treat cancers.

Volastra has raised $45M in funding to date.  This includes capital from top US and European venture firms, including Vida, Polaris, Droia, and Arch.  Current funding will look to advance a lead program into the clinic, advance another program to IND-enabling studies and strengthen the platform to identify a broader pipeline of candidates. The company has a world class scientific advisory board including two Nobel Laureates as well as a highly experienced senior leadership team.  This includes the CEO, CSO and senior leaders with expertise in chemistry, biochemistry, biology, immunology, and operations.

In addition, Volastra has recently announced a multi-year up to $1.1B drug discovery collaboration with Bristol Myers Squibb.  This high visibility and important collaboration will leverage Volastra’s proprietary CINtech platform, to identify CIN-related, synthetic lethal targets as drug candidates.  The success of this collaboration will be critical to the growth of the company.

The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and all most other areas of the city and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of RA or Sr. RA at Volastra will work closely with the scientific team to achieve the company’s scientific and strategic plan.  Volastra is seeking a highly motivated researcher for an in vitro biology lab-based role. The RA will have responsibility for designing and executing experiments as part of the scientific team to ensure the advancement of key programs in the Volastra pipeline. Our ideal candidate is an independent thinker with excellent communication skills who may provide insights towards experiment design and interpretation and is also a team player who may take on responsibilities outside his/her scope of work. The candidate should have a track-record of consistent experimentation, experience with in vitro assays relevant to cancer biology, integrity, and tangible contributions to biopharmaceutical drug programs and/or peer-reviewed publications. Project responsibilities will include, but are not limited to:

  • Validation of key targets using the company’s unique platform centered on CIN and metastasis
  • Interrogating the biology of CIN and metastasis to yield new mechanistic insights
  • Developing assays to best evaluate therapeutic potential of CIN-targeting therapies
  • Using measures of CIN to build novel datasets

Required Skills

  • Cancer cell line culture and genetic engineering (Lentiviral transduction, overexpression, RNAi and/or CRISPR/Cas9)
  • Cell-based phenotypic assays such as proliferation or cytotoxicity
  • Molecular biology techniques such as PCR, RT-qPCR and Western Blot
  • Data analysis and presentation through software such as Graphpad Prism, Microsoft Excel and Powerpoint
  • Time management to independently meet deadlines

Preferred Skills (but not required)

  • Confocal and/or high-content microscopy including live imaging
  • Flow Cytometry
  • Benchling inventory/registry/ELN system

QUALIFICATIONS

  • Bachelor’s or Master’s Degree in a relevant field such as cell biology or cancer biology
  • 2+ years cancer biology laboratory experience in an academic and/or industry setting
  • Ability to work independently
  • Excellent communication skills

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.