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Our Culture

We are a world-class team translating a pioneering understanding of basic biology into a powerful new class of cancer therapies.

When we say we’re a team, we mean it. We support one another. We challenge one another. We learn from one another. And we always lend a hand.

We have 15,000 square feet of office and lab space in New York City, the greatest city in the world. When we can’t be there in person, we find ways to maintain our connections over Zoom. (Case in point: A recent team cooking class. Who would have thought seasoning paella could be a bonding experience?)

We’re here to turn breakthrough science into therapies that can stop cancer at its outset.

Our Values

Current Openings

Position Location
Associate Director/Director, Program Management New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Our lead program, a KIF18A inhibitor, is on track to enter the clinic in the second half of 2023 for patients with advanced cancer.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch. Volastra recently announced a multi-year up to $1.1B drug discovery collaboration with Bristol Myers Squibb leveraging Volastra’s proprietary CINtech platform to identify CIN-related targets. In addition, Volastra has a partnership with Microsoft to develop AI technologies for the interrogation of CIN.  The company has a world class advisory board including two Nobel Laureates as well as a highly experienced senior leadership team. The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and most other areas of the city, Westchester County, and New Jersey.

JOB DESCRIPTION

Volastra is seeking a highly motivated and experienced individual who will be responsible for supporting cross-functional drug development activities to achieve the company’s scientific and strategic goals. The Associate Director/Director, Program Management will partner with program and functional leaders and work in close collaboration with the Development Team, sub-teams and co-development partners to advance the company’s R&D portfolio, shape and execute the project and portfolio strategies through the project lifecycle. The successful candidate displays a diverse range of interpersonal skills, has effective communication, organizational, analytical, and problem-solving skills, coupled with enthusiasm, motivation, and ability to lead and collaborate within teams. The role reports to and will work closely with the VP, Development Leadership.

This is an exciting opportunity for a qualified candidate to join the dedicated and talented team at Volastra in support of the company’s growth and development efforts. Volastra is a lean team of dedicated individuals working to advance therapies for patients with advanced cancer. As such, the individual will have the opportunity to work on projects and take on responsibilities that may fall outside of his/her scope of work. 

JOB RESPONSIBILITIES

  • Work in coordination with the Development Lead as well as scientific and functional leads to develop and maintain high-quality, integrated project plans and timelines that align with overall program and corporate strategy and drive communication, scenario planning and decision making
  • Facilitate effective, science-based business decisions through scenario planning, highlighting potential downstream impacts of strategic decision making (including resource allocation, team capacity, risk and overall portfolio management)
  • Facilitate the identification, management and communication of key program risks and their associated mitigation and contingency plans
  • Work collaboratively and cross-functionally to coordinate, influence and manage efforts to ensure seamless execution of the global development strategy
  • Provide program and project management support for key functional activities including functional sub-team and working group meeting support, regulatory submission planning and management of external contractors/vendors as indicated
  • In partnership with the Development Team prepare a Strategic Development Plan to govern program strategy
  • Develop and coordinate ongoing resource planning across functions to ensure adequate resources are applied to the project at any given time
  • Leverage strong project and organizational knowledge, leadership and facilitation skills to optimize team meetings and facilitate effective governance and decision making
  • Develop and implement stage appropriate and value-added processes, best practices and tools (integrated timelines, TPPs, stage gate process, governance, core & sub team processes) to increase efficiency and consistency of global product development and team processes/deliverables
  • Advance program and alliance management best practices and contribute to the operational excellence of Volastra with a focus on continuous improvement
  • Build and leverage relationships and networks and contribute to fostering high-performing and high functioning teams through team norms and operating principles; proactively identify opportunities and removing obstacles to drive business results
  • Manage the scientific communications plans for the project(s) and integrate with overall corporate communications plan
  • Prepare monthly progress reports and ad hoc reports as required
  • Support planning and integration of early research efforts in support of the company pipeline and strategic goals
  • Other responsibilities as assigned

QUALIFICATIONS

  • Bachelor’s Degree (BSc) required; advanced degree (MSc, PhD, PharmD) preferred. 
  • Minimum of 5-7 years of experience in the pharmaceutical/biotech industry, with experience managing cross-functional drug development programs
  • Drug development knowledge with understanding of functions relevant to advancing the program, such as Research, Preclinical, Clinical, Manufacturing, Regulatory and Commercial
  • Excellent business acumen, demonstrated ability to align teams to strategy to achieve business and project objectives
  • Experience leading and facilitating project team meetings, cross-functional communication and decision making, and ensuring ongoing alignment with internal/external stakeholders
  • A proactive and strategic thinker, with strong facilitation, problem-solving and issue resolution skills
  • Highly collaborative with outstanding communication and relationship management skills, high emotional intelligence
  • Adaptive leadership style adept at influencing teams without formal authority and ability to work effectively with cross-functional teams in a highly matrixed global organization
  • PMP credential and experience with latest PM tools, software and processes is valued
  • Oncology drug development experience and prior experience working with external consultants/vendors is desirable 
  • Job Location: New York City, hybrid
Associate Director/Director/Sr Director, DMPK New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Our lead program, a KIF18A inhibitor, is on track to enter the clinic in the second half of 2023 for patients with advanced cancer.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch. Volastra recently announced a multi-year up to $1.1B drug discovery collaboration with Bristol Myers Squibb leveraging Volastra’s proprietary CINtech platform to identify CIN-related targets. In addition, Volastra has a partnership with Microsoft to develop AI technologies for the interrogation of CIN.  The company has a world class advisory board including two Nobel Laureates as well as a highly experienced senior leadership team. The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and most other areas of the city, Westchester County, and New Jersey.

JOB DESCRIPTION 

The Associate Director/Director/Senior Director of DMPK will report directly to the Vice President of Chemistry and work closely will partner with the Scientific Project Leaders to successfully shape and execute the relevant PK/ADME portions of the project to support the overall drug development strategies from early discovery through clinical development.  Job responsibilities will include, but are not limited to:

  1. Serve as the DMPK subject matter expert for nonclinical development
  2. Manage CROs in the conduct of in vitro/in vivo ADME and DMPK modeling studies
  3. Prepare strategic, innovative, and scientifically sophisticated PK/ADME drug development strategies that meet regulatory requirements and program goals
  4. Design, execute and interpret non-clinical pharmacology, toxicology, DMPK and translational studies supporting progression of therapies from early discovery through first in human and proof of concept clinical studies
  5. Prepare high quality preclinical and translational DMPK work packages to support projects in lead optimization and clinical candidate selection as well as any associated regulatory filings
  6. Design preclinical studies and report results to project teams to evaluate and optimize series and compounds towards a selected candidate with acceptable and predictable clinical PK properties and drug-drug interaction profile
  7. Collaborate with scientific team and clinical development to characterize human pharmacokinetics, metabolism, and biopharmaceutics of clinical compounds
  8. Assess and communicate DMPK results to senior management to support key go, no-go decisions
  9. Build, manage and coach a team of high performing subject matter experts to support research and clinical programs, as needed

Skills and requirements

  • Ph.D. degree in relevant scientific field and greater than 8 years’ experience with DMPK in drug discovery in a Pharmaceutical or Biotech setting, or M.Sc. degree and greater than 12 years relevant industrial experience.
  • Broad experience with in vitro and in vivo preclinical assays and their application to predict human ADME and potential DDI.
  • Ability to collaborate on the discovery of clinical leads, and the preclinical characterization of leads to identify clinical candidates
  • Experience with IND filings
  • Strong communication skills, with the ability to work on fast-moving, collaborative, cross-functional teams

Volastra is a lean team of dedicated individuals working to advance therapies for patients with metastatic cancer.  As such, the Associate Director/Director/Senior Director of DMPK will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.

 

Director, Clinical Science, Oncology New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Our lead program, a KIF18A inhibitor, is on track to enter the clinic in the second half of 2023 for patients with advanced cancer.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch. Volastra recently announced a multi-year up to $1.1B drug discovery collaboration with Bristol Myers Squibb leveraging Volastra’s proprietary CINtech platform to identify CIN-related targets. In addition, Volastra has a partnership with Microsoft to develop AI technologies for the interrogation of CIN.  The company has a world class advisory board including two Nobel Laureates as well as a highly experienced senior leadership team. The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and most other areas of the city, Westchester County, and New Jersey.

Please visit www.volastratx.com for more information

JOB DESCRIPTION

The role of Director, Clinical Science, Oncology, will work collaboratively with the study physician and the cross functional team to manage clinical activities that will bring novel cancer therapeutics to patients in need. The role will be accountable for the clinical science aspects of clinical development programs. The ideal candidate is self-motivated, curious, detail oriented, works collaboratively and has highly relevant experience and expertise. Volastra is a fast-paced biotech company of passionate employees, and there is ample opportunity for the ideal candidate to grow and develop with the organization.

Responsibilities include:

  • Acts as a key member of the clinical study team with relevant expertise in clinical science and clinical trial conduct, execution, and data interpretation.
  • Works closely and collaboratively with clinical operations and CRO/vendors in planning and execution of clinical study deliverables from initiation to closeout.
  • With oversight from study physician, responsible for: raising and tracking investigator/CRF queries to resolution, first-line medical monitoring, clinical data review, data trend review, protocol deviation review, data cleaning, interpretation of results, review of safety narratives, and safety reporting.
  • With clinical operations lead, assures appropriate oversight of study conduct.
  • Develops and manages tools to track clinical data
  • Builds key relationships with external partners, sites, and investigators and, with clinical operations lead, organizes study committees and boards as needed.
  • Authors and/or reviews, with support from the clinical study team, clinical study plans and documents (e.g. CRF pages, CRF completion guidelines, medical monitoring plan, data management plan, ICFs, patient eligibility forms, or other clinical or regulatory documents as needed).
  • Develops relevant site facing clinical study training materials.
  • With support from clinical leadership and study physician, plays a key role in the development and authorship of clinical protocol(s) and any amendments., as well as any related documents.
  • With support from clinical leadership and study physician, provides clinical input and authorship for CSRs, clinical memorandums, and other key documents (e.g. IB, PSUR, DSUR, responses to regulatory authorities, etc.).
  • Works closely and collaboratively with CRO clinical staff (and sites as needed) to support clinical aspects of the study including: study start up, training, subject screening and enrollment, study conduct, data and sample collection, and close out activities.
  • With oversight from study physician, advises sites on accurate interpretation of protocol to ensure protocol adherence.
  • With clinical study team, manages and monitors clinical sites and their performance from a clinical perspective.
  • Responsible for timely delivery of relevant and accurate clinical data and data interpretation as needed for investigator calls, dose-escalation calls, and all other study, regulatory, or company milestones.
  • Works closely with data management partners to design clinical databases and assure complete and accurate collection of study data.
  • Escalates any important issues that involve patient safety or data integrity to study physician.

REQUIREMENTS

  • Bachelor’s degree required, advanced degree or degree in clinically related field a plus.
  • 10 years experience, with at least 5 in clinical development and at least 3 in an oncology clinical science role.
  • Deep understanding and experience in conduct of clinical trials including first-in-human oncology studies.
  • Experience contributing to clinical protocols and key study documents.
  • Strong knowledge of medical monitoring, clinical data cleaning and interpretation, database management, good clinical practice, and relevant regulatory requirements.
  • Proven track record of collaborative work to achieve program objectives.
  • Commitment to patient safety, data integrity, teamwork, and successful conduct of clinical programs.
  • Excellent written and verbal communication skills.
  • Excellent organizational and time management skills

PREFERRED SKILLS (but not required)

  • Data Management and/or database build skills
  • Experience in Safety and Pharmacovigilance operations
  • Experience interacting with regulatory agencies
  • Experience in sample management
  • Strong understanding of basic science

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, individuals will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.   Job is based in NYC with a flexible option for hybrid work.

Director, Data Science New York, NY

COMPANY

Volastra Therapeutics, Inc. is a biotechnology company based in New York City, formed from the laboratory of Dr. Lewis Cantley, along with Drs. Olivier Elemento and Samuel Bakhoum.  Volastra is dedicated to the discovery and development of treatments for patients with cancer.  The Company’s therapies will target novel pathways and apply insights gained from its scientific founders into chromosomal instability (CIN) and its clear association with the formation, progression, and maintenance of disease.  Our lead program, a KIF18A inhibitor, is on track to enter the clinic in the second half of 2023 for patients with advanced cancer.

Volastra has raised funding from top US and European venture firms, including Vida, Polaris, Droia, and Arch. Volastra recently announced a multi-year up to $1.1B drug discovery collaboration with Bristol Myers Squibb leveraging Volastra’s proprietary CINtech platform to identify CIN-related targets. In addition, Volastra has a partnership with Microsoft to develop AI technologies for the interrogation of CIN.  The company has a world class advisory board including two Nobel Laureates as well as a highly experienced senior leadership team. The company operates out of 15,000 square feet of office and state-of-the-art laboratory space in West Harlem, New York City, within easy traveling distance of Columbia, Cornell, Memorial Sloan Kettering, and most other areas of the city, Westchester County, and New Jersey.

JOB DESCRIPTION

The Director, Data Science will work closely with the Head of Data Science and the entire scientific team to achieve the company’s integrative data-centric approach to identify novel targets and develop therapeutics to treat chromosomally unstable cancers.  If you enjoy the prospect of improving the lives of cancer patients using advanced computational methods, this may the role for you.

In your first 6 months, your team will have the opportunity to materially impact the Volastra pipeline with novel analyses informing target selection and validation using integrative methods on both proprietary and external datasets (RNA-Seq, Whole Exome Sequencing, etc.).  Your team will build unique data pipelines as well as analyze their outputs for our project teams.  You and your team have the opportunity to explore novel statistical inference techniques, which could include multi-modality data fusion (genomic, imaging, and clinical data), machine learning, and dynamic systems modeling.

You will also:

  1. Work collaboratively with the scientific team including biologists, computational biologists, data scientists, and chemists to answer complex questions in a data-driven manner
  2. Contribute to building a team and culture that embraces scientific excellence and integrity with a sense of collaboration internally and externally.
  3. Clearly communicate key findings to members of the scientific and leadership teams.
  4. Provide leadership to less experienced staff, including setting priorities, managing to a deadline, and fostering development opportunities for those on your team.

You have:

  • A graduate degree in bioinformatics, computational biology, bioengineering, or other relevant quantitative discipline (statistics, mathematics, engineering, etc)
  • 5+ years of previous work experience in data science-related roles at the intersection of biology, immunology, or translational medicine
  • A deep understanding of statistical analysis methods, data engineering, and genomic pipeline development
  • Scientific or quantitative computing experience (Python or R), plus bash scripting
  • Familiarity with high-performance cluster and cloud computing (aws, Azure, spark)
  • An understanding of best practices in reproducible scientific computing (git, documentation, object oriented programming, etc)
  • Familiarity with common bioinformatics software and toolkits, such as NextFlow, deseq2, samtools, GATK, and STAR
  • Experience working with multidisciplinary teams and leveraging large public datasets to facilitate novel target discovery and refine patient selection strategies.
  • Past involvement or leadership in immune-oncology projects is a plus.
  • The ability to tell a story with data (analysis, data visualization)

Volastra is a lean team of dedicated individuals working to advance therapies for patients with cancer.  As such, the Scientist will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work.