SHIFTING PARADIGMS
IN ONCOLOGY

Volastra targets chromosomal instability,
signaling a new era in cancer treatment

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    References:

    1. Burrell RA, McGranahan N, Bartek J, Swanton C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature. 2013;501(7467):338-345.
    2. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396(6712):643-649.
    3. Bakhoum SF, Cantley LC. The multifaceted role of chromosomal instability in cancer and its microenvironment. Cell. 2018;174(6):1347-1360.
    4. Primo LMF, Teixeira LK. DNA replication stress: oncogenes in the spotlight. Genet Mol Bio. 2020;43(1)(suppl 1):1-14.