Senior Scientist/Associate Director, Bioinformatics

Location: New York, New York, United States


Volastra Therapeutics, Inc. is a clinical stage oncology biotechnology company based in New York City.  Founded by Lewis Cantley, Samuel Bakhoum and Olivier Elemento, Volastra is focused on developing therapeutics that exploit chromosomal instability (CIN) as a unique vulnerability in cancer. The company has grown since its founding in 2019 and now supports ongoing discovery efforts as well as a growing clinical organization.  

Volastra's most advanced pipeline medicines are two distinct inhibitors of KIF18A, a novel therapeutic target. The first medicine, VLS-1488 was internally discovered and is currently in Phase I for the treatment of advanced cancers.  The second KIF18A inhibitor is sovilnesib, a clinical stage KIF18A inhibitor licensed from Amgen in February 2023 and for which the company is in the process of initiating in Q2 2024.  

Volastra is financed by top US and European venture firms, including Arch Ventures, Polaris, Vida, Droia, Catalio as well as from strategic investor Eli Lilly. In addition to venture funding, Volastra has a multi-year drug discovery collaboration with Bristol Myers Squibb and a biomarker discovery partnership with Microsoft to use artificial intelligence to measure chromosomal instability. The company has a highly experienced senior leadership team and a world class advisory board.  

The company operates out of office and laboratory space in West Harlem, New York City, within easy traveling distance of most areas of the city, Westchester County, and New Jersey. Please visit for more information. 


The role of Senior Scientist/Associate Director Bioinformatics will report to the Head of Immunology and Data Science and work closely with the entire research organization to support the successful development of our clinical stage assets and advancement of preclinical programs.  We are actively seeking a bioinformatics expert with experience in multi-modal data analysis to support research efforts across the organization. 

The ideal candidate works collaboratively, is detail-oriented, creative, self-motivated, has a strong background in cancer biology, computational biology, statistics, machine learning, or a related field, and has experience working in cross-functional teams.      

Volastra is a fast-paced biotech company of passionate employees, and there is ample opportunity for the ideal candidate to grow and develop within the organization.


  • Use relevant and robust analytical methodologies to uncover, interpret, and validate insights into preclinical and clinical programs using complex biological datasets encompassing genomic, transcriptomic, proteomic, imaging, and other data types to inform target identification, biomarkers, and patient selection strategies  
  • Critically assess and clearly communicate strengths, limitations and caveats of specific datasets to ensure high quality research and appropriate data interpretation
  • Work directly with scientists to optimize experimental designs to fulfill statistical and data science needs.
  • Clearly and comprehensively document and communicate research findings to internal teams, scientific leadership and other key stakeholders
  • Contribute to building a team and culture that embraces scientific excellence and integrity with a sense of collaboration both internally and externally  


  • PhD or Master’s degree in Bioinformatics, Computational Biology, or a related discipline, with a strong foundation in cancer biology and/or immune-oncology
  • At least 3-5 years of post-graduate experience in a bioinformatics role, preferably with a focus on oncology or immune-oncology
  • Fluency in programming and tools relevant to bioinformatics and statistical analysis (e.g. Python, R), and experience with machine learning and cancer-related datasets (e.g. GDC, TCGA, DepMap)
  • Exceptional analytical skills and the ability to manage complex projects involving multi-dimensional data
  • Direct experience with genome sequencing analysis methods and experimental design, including next-generation sequencing and array-based platforms
  • Excellent communication and collaboration skills, with proven experience in making complex data and analyses accessible across diverse audiences
  • Experience working with cloud computing environments such as AWS and Databricks
  • A track record of peer-reviewed publications in relevant fields would be advantageous


  • Familiarity with best practices for software development (e.g. code review, version control)
  • Direct experience developing, validating and deploying genomic and/or transcriptomic analysis pipelines
  • Prior experience generating biological insights from statistical analyses of imaging data

Volastra is a team of dedicated individuals working to advance therapies for patients with cancer.  As such, individuals will from time to time have the opportunity to work on projects and take on responsibilities that may fall outside his/her scope of work. Job is based in NYC with a flexible option for hybrid work.


Approximately $140,000- $195,000 which may vary depending on qualifications, experience, and ultimate leveling